abstract：:Ubiquitination is a post-translational modification that can dynamically alter the function, degradation and transport of a protein, as well as its interaction with other proteins, and activity of an enzyme. Dysfunctional ubiquitination is detrimental to normal cellular functions, and can result in severe diseases. Ov...

journal_title：Neuroscience

authors： Zhu J,Tsai NP

更新日期：2020-01-21 00:00:00

abstract：:Major illnesses, including heart attack and sepsis, can cause cognitive impairments, depression, and progressive memory decline that persist long after recovery from the original illness. In rodent models of sepsis or subchronic immune challenge, memory deficits also persist for weeks or months, even in the absence of...

journal_title：Neuroscience

authors： Tchessalova D,Tronson NC

更新日期：2020-01-21 00:00:00

abstract：:The specific mechanism of migraine chronification remains unclear. We previously demonstrated that synaptic plasticity was associated with migraine chronification. EphB receptors and their ligands, ephrinBs, are considered to be key molecules regulating the synaptic plasticity of the central nervous system. However, w...

journal_title：Neuroscience

authors： Wang J,Fei Z,Liang J,Zhou X,Qin G,Zhang D,Zhou J,Chen L

更新日期：2020-01-21 00:00:00

abstract：:The effects of muscle fatigue are known to be altered in older adults, and age-related changes in the brain are likely to be a contributing factor. However, the neural mechanisms underlying these changes are not known. The aim of the current study was to use transcranial magnetic stimulation combined with electroencep...

journal_title：Neuroscience

authors： Opie GM,Otieno LA,Pourmajidian M,Semmler JG,Sidhu SK

更新日期：2020-01-15 00:00:00

abstract：:Organophosphorus (OP) compounds are deadly chemicals that exert their intoxicating effects through the irreversible inhibition of acetylcholinesterase (AChE). In addition to an excess of peripheral ailments, OP intoxication induces status epilepticus (SE) which if left untreated may lead to permanent brain damage or d...

journal_title：Neuroscience

authors： Barker BS,Spampanato J,McCarren HS,Smolik M,Jackson CE,Hornung EN,Yeung DT,Dudek FE,McDonough JH

更新日期：2020-01-15 00:00:00

abstract：:In several tauopathies such as Alzheimer's disease (AD), an increased incidence of seizures is observed. Tau, one of the major proteins implicated in AD pathology, is an important regulator of neural network excitability and might participate in the underlying epileptic cascade. However, the mechanisms underlying this...

journal_title：Neuroscience

authors： Van Erum J,Valkenburg F,Van Dam D,De Deyn PP

更新日期：2020-01-15 00:00:00

abstract：:Alzheimer's disease (AD) is a debilitating disease and the most common cause of dementia. As the world population ages even modest advances in therapies and preventative strategies would be of benefit. The specific physiological function of the amyloid precursor protein (APP) remains unclear despite strong genetic and...

journal_title：Neuroscience

authors： Bamford RA,Widagdo J,Takamura N,Eve M,Anggono V,Oguro-Ando A

更新日期：2020-01-01 00:00:00

abstract：:Dopamine is a neurotransmitter crucial for motor, motivational, and reward-related functions. Our aim was to determine the effect of a palatable maternal diet on the transcriptional regulation of dopaminergic-related genes during perinatal development of rat offspring. For that, female offspring from dams fed with a c...

journal_title：Neuroscience

authors： Rossetti MF,Schumacher R,Gastiazoro MP,Lazzarino GP,Andreoli MF,Stoker C,Varayoud J,Ramos JG

更新日期：2020-01-01 00:00:00

abstract：:Extensive research over the past decades has characterized multiple forms of synaptic plasticity, identifying them as key processes that allow the brain to operate in a dynamic manner. Within the wide variety of synaptic plasticity modulators, kainate receptors are receiving increasing attention, given their diversity...

journal_title：Neuroscience

authors： Valbuena S,Lerma J

更新日期：2019-12-19 00:00:00

abstract：:Non-synaptic transmission is pervasive throughout the nervous system. It appears especially prevalent in peripheral ganglia, where non-synaptic interactions between neighboring cell bodies have been described in both physiological and pathological conditions, a phenomenon referred to as cross-depolarization (CD) and t...

journal_title：Neuroscience

authors： Carvalho GB,Mulpuri Y,Damasio A,Spigelman I

更新日期：2019-12-15 00:00:00

abstract：:Brain connectivity studies have reported that functional networks change with older age. We aim to (1) investigate whether electroencephalography (EEG) data can be used to distinguish between individual functional networks of young and old adults; and (2) identify the functional connections that contribute to this cla...

journal_title：Neuroscience

authors： Moezzi B,Pratti LM,Hordacre B,Graetz L,Berryman C,Lavrencic LM,Ridding MC,Keage HAD,McDonnell MD,Goldsworthy MR

更新日期：2019-12-01 00:00:00

abstract：:Repetitive mild traumatic brain injury (rmTBI; e.g., sports concussions) is common and results in significant cognitive impairment, white matter injury and increased risk of neurodegeneration. Targeted therapies for rmTBI are lacking, though evidence from other injury models indicates that targeting N-methyl-d-asparta...

journal_title：Neuroscience

authors： Ma G,Liu C,Hashim J,Conley G,Morriss N,Meehan WP,Qiu J,Mannix R

更新日期：2019-11-21 00:00:00

abstract：:Successive fusion events between transport vesicles and their target membranes mediate trafficking of secreted, membrane- and organelle-localised proteins. During the initial steps of this process, termed the secretory pathway, COPII vesicles bud from the endoplasmic reticulum (ER) and fuse with the cis-Golgi membrane...

journal_title：Neuroscience

authors： Jepson JEC,Praschberger R,Krishnakumar SS

更新日期：2019-11-10 00:00:00

abstract：:Synaptic vesicle protein 2A (SV2A), which plays an important role in the pathophysiology of epilepsy, is a unique vesicular protein recognized as a pharmacological target of anticonvulsant drugs. Furthermore, SV2A is a potential synaptic density marker, as it is ubiquitously expressed throughout the brain in all nerve...

journal_title：Neuroscience

authors： Mendoza-Torreblanca JG,García-Cruz ME,Sánchez-Cruz I,Gomez-Gonzalez B,Juárez-Méndez S,Gómez-Lira G

更新日期：2019-11-01 00:00:00

abstract：:Agrin is a multi-domain protein best known for its essential function during formation of the neuromuscular junction. Alternative mRNA splicing at sites named y and z in the C-terminal part of agrin regulates its interaction with a receptor complex consisting of the agrin-binding low-density lipoprotein receptor-relat...

journal_title：Neuroscience

authors： Handara G,Kröger S

更新日期：2019-11-01 00:00:00

abstract：:Deep brain stimulation of the anterior nucleus of the thalamus has been proposed as novel therapy to treat intractable epilepsy. To optimize this approach, we proposed to study the involvement of this nucleus in a non-human primate model of mesial temporal lobe seizure. Two macaques were implanted with one chronic ele...

journal_title：Neuroscience

authors： Sherdil A,Coizet V,Pernet-Gallay K,David O,Chabardès S,Piallat B

更新日期：2019-10-15 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is triggered by exposure to traumatic events, but not everyone who experiences trauma develops this disorder. Like humans, PTSD-like symptoms develop in some laboratory rodents (susceptible individuals), while others express less or no symptoms (resilient individuals). Here, consi...

journal_title：Neuroscience

authors： Lguensat A,Bentefour Y,Bennis M,Ba-M'hamed S,Garcia R

更新日期：2019-10-15 00:00:00

abstract：:Cognitive impairment is one of the common non-motor symptoms in Parkinson's disease (PD). The hippocampus is a critical structure for learning and memory processes. The abnormal synaptic plasticity in the hippocampus is suggested to be associated with cognitive dysfunction in PD. Voltage gated sodium channels (VGSCs) ...

journal_title：Neuroscience

authors： Wang Z,Lin Y,Liu W,Kuang P,Lao W,Ji Y,Zhu H

更新日期：2019-10-15 00:00:00

abstract：:Clinical reports show that oxytocin (OT) is related to stress-related disorders such as depression, anxiety disorder, and post-traumatic stress disorder. Two key structures in the brain should be paid special attention with regard to stress regulation, namely, the hypothalamus and the hippocampus. The former is the re...

journal_title：Neuroscience

authors： Matsushita H,Latt HM,Koga Y,Nishiki T,Matsui H

更新日期：2019-10-01 00:00:00

abstract：:Colivelin is a neuroprotective humanin family peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. We seek to investigate whether this effect of Colivelin also govern ischemic brain injury, and potential mechanism underlying th...

journal_title：Neuroscience

authors： Zhao H,Feng Y,Wei C,Li Y,Ma H,Wang X,Cui Z,Jin WN,Shi FD

更新日期：2019-09-15 00:00:00

abstract：:p53 and parkin are involved in mitochondrial quality control. The present study aimed to characterize the functional significance of parkin/p53 in the development of mitochondrial dysfunction and the pathophysiology of neuropathic pain in type I diabetes. Type I diabetes was induced in mice (N = 170) using streptozoto...

journal_title：Neuroscience

authors： Yamashita A,Matsuoka Y,Matsuda M,Kawai K,Sawa T,Amaya F

更新日期：2019-09-15 00:00:00

abstract：:How obesity exacerbates migraine and other pain disorders remains unknown. Trigeminal nociceptive processing, crucial in migraine pathophysiology, is abnormal in mice with diet induced obesity. However, it is not known if this is also true in genetic models of obesity. We hypothesized that obese mice, regardless of th...

journal_title：Neuroscience

authors： Rossi HL,Raj NR,Marquez de Prado B,Kuburas A,Luu AKS,Barr GA,Recober A

更新日期：2019-09-01 00:00:00

abstract：:The dopamine D2 receptor (DRD2) and dopamine transporter (DAT) play a regulatory role in dopaminergic neurotransmission and thus play an important role in drug addiction. The prefrontal cortex (PFC), a critical part of the mesencephalic dopaminergic system, is thought to be involved in the development and maintenance ...

journal_title：Neuroscience

authors： Sun Z,Ma Y,Xie L,Huang J,Duan S,Guo R,Xie Y,Lv J,Lin Z,Ma S

更新日期：2019-09-01 00:00:00

abstract：:People commonly synchronize taps to rhythmic sounds and can continue tapping after the sounds stop, indicating that time intervals between sounds can be internalized. Here, we investigate what happens in the brain after simply listening to auditory beats in order to understand more about the automatic internalization ...

journal_title：Neuroscience

authors： Graber E,Fujioka T

更新日期：2019-08-10 00:00:00

abstract：:Parkinson's disease (PD) is a common movement disorder. Alpha-synuclein (α-synuclein) plays a critical role in PD. In this study, we evaluated the level of central nervous system (CNS)-derived exosomal α-synuclein in serum, which may be regarded as a specific peripheral biomarker for PD. We recruited patients with PD ...

journal_title：Neuroscience

authors： Si X,Tian J,Chen Y,Yan Y,Pu J,Zhang B

更新日期：2019-08-10 00:00:00

abstract：:A single session of aerobic exercise may offer one means to "prime" motor regions to be more receptive to the acquisition of a motor skill; however, the mechanisms whereby this priming may occur are not clear. One possible explanation may be related to the post-translational modification of plasticity-related receptor...

journal_title：Neuroscience

authors： Thacker JS,Xu Y,Tang C,Tupling AR,Staines WR,Mielke JG

更新日期：2019-08-01 00:00:00

abstract：:Hippocampal oscillations, particularly theta (6-12 Hz) and gamma (30-90 Hz) frequency bands, play an important role in several cognitive functions. Theta and gamma oscillations show cross-frequency coupling (CFC), wherein the phase of theta rhythm modulates the amplitude of the gamma oscillation, and this CFC is belie...

journal_title：Neuroscience

authors： Nakazono T,Takahashi S,Sakurai Y

更新日期：2019-08-01 00:00:00

abstract：:Calpain-mediated tau cleavage into the neurotoxic tau45-230 fragment plays an important role in Alzheimer's disease (AD). This tau fragment accumulates mainly in the cytoplasm of degenerating neurons. However, subcellular localization studies indicated that a pool of tau45-230 associates with the cytoskeleton in hippo...

journal_title：Neuroscience

authors： Afreen S,Ferreira A

更新日期：2019-08-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive aging disorder that affects millions worldwide, thus, disease-modifying-therapies are urgently needed. PD pathology includes α-synuclein (aSyn) accumulation as synucleinopathy. Loss of GM1 gangliosides occurs in PD brain, which is modeled in GM2 synthase transgenic mice. GM2+/...

journal_title：Neuroscience

authors： Vidal-Martinez G,Najera K,Miranda JD,Gil-Tommee C,Yang B,Vargas-Medrano J,Diaz-Pacheco V,Perez RG

更新日期：2019-07-15 00:00:00

abstract：:Individuals continuously confronted with various stresses in modern life generate high levels of cortisol (corticosterone in rodents), the major glucocorticoid secreted by adrenal gland when hypothalamic-pituitary-adrenal axis is activated. Chronic stress can induce constant release of glucocorticoid and cause many se...

journal_title：Neuroscience

authors： Jiang Y,Botchway BOA,Hu Z,Fang M

更新日期：2019-07-15 00:00:00

abstract：:The sphenopalatine ganglion (SPG) is a gathering of the cell bodies of parasympathetic fibers that dominate the nasal gland, lacrimal gland and cerebral blood vessels. The SPG controls nasal secretions, tears, and the dilation of cerebral blood vessels. However, it is unclear how serotonin regulates SPG functions. In ...

journal_title：Neuroscience

authors： Ishida Y,Sugiura Y,Magome T,Kamakura T,Takimoto Y,Hanada Y,Kitayama K,Nakamura Y,Shimada S,Ohta N,Naono-Nakayama R,Kamijo K

更新日期：2019-07-15 00:00:00

abstract：:Response inhibition is a central aspect of cognitive control. Usually, response inhibition is examined using information from a single sensory modality. Yet, evidence suggests that conflicts between information from different modalities affect response inhibition. It is, however, crucial to consider that there are mod...

journal_title：Neuroscience

authors： Friedrich J,Beste C

更新日期：2019-07-01 00:00:00

abstract：:Sestrin2 (Sesn2) is a stress response protein which expresses neuroprotective characteristics in some neurodegenerative disorders. However, the impact of Sesn2 on the clinical outcome of stroke is unclear. The nuclear factor-erythroid 2 related factor 2/heme oxygenase-1 (Nrf2/HO-1) pathway is a key factor in angiogene...

journal_title：Neuroscience

authors： Wang P,Zhao Y,Li Y,Wu J,Yu S,Zhu J,Li L,Zhao Y

更新日期：2019-07-01 00:00:00

abstract：:Excitotoxicity plays an important role in the pathogenesis of developing brain injury. The neuropeptide secretoneurin (SN) has neuroprotective potential. The aim of this study was to investigate SN plasma concentrations following excitotoxicity and to evaluate the effect of SN as therapeutic strategy in excitotoxic ne...

journal_title：Neuroscience

authors： Posod A,Wechselberger K,Schmid A,Huber E,Urbanek M,Kiechl-Kohlendorfer U,Griesmaier E

更新日期：2019-07-01 00:00:00

abstract：:Before movement onset, during the reaction time, excitability of M1 is selectively modulated by somatosensory inputs, only in the movement-related muscle. If a similar mechanism operates before the onset of mental movements, then somatosensory afferent inputs are exploited during cognitive representation of movement. ...

journal_title：Neuroscience

authors： Bonassi G,Bisio A,Lagravinese G,Ruggeri P,Bove M,Avanzino L

更新日期：2019-06-15 00:00:00

abstract：:Voltage-gated Ca2+ channels (VGCCs) play key roles in auditory perception and information processing within the inner ear and brainstem. Pharmacological inhibition of low voltage-activated (LVA) T-type Ca2+ channels is related to both age- and noise induced hearing loss in experimental animals and may represent a prom...

journal_title：Neuroscience

authors： Lundt A,Seidel R,Soós J,Henseler C,Müller R,Bakki M,Arshaad MI,Ehninger D,Hescheler J,Sachinidis A,Broich K,Wormuth C,Papazoglou A,Weiergräber M

更新日期：2019-06-15 00:00:00

abstract：:The subplate (SP) represents a transitory cytoarchitectural fetal compartment containing most subcortical and cortico-cortical afferents, and has a fundamental role in the structural development of the healthy adult brain. There is evidence that schizophrenia and autism may be determined by developmental defects in th...

journal_title：Neuroscience

authors： Serati M,Delvecchio G,Orsenigo G,Mandolini GM,Lazzaretti M,Scola E,Triulzi F,Brambilla P

更新日期：2019-06-01 00:00:00

abstract：:Rapid changes in the light-dark cycle cause circadian desynchronization between rhythms of spike-wave discharges (SWDs) and motor activity in genetic epileptic rats, and this is accompanied by an increase in epileptic activity. Given the close relationship between absence seizures and sleep-wake states, the present st...

journal_title：Neuroscience

authors： Smyk MK,van Luijtelaar G,Huysmans H,Drinkenburg WH

更新日期：2019-06-01 00:00:00

abstract：:Locomotion involves complex combinations of translational and rotational head movements. For gaze stability, this necessitates the interplay of angular and linear vestibulo-ocular reflexes (VOR) as well as the integration of visual feedback about the desired viewing distance. Furthermore, gaze stabilizing systems must...

journal_title：Neuroscience

authors： Dietrich H,Wuehr M

更新日期：2019-06-01 00:00:00

abstract：:M1 muscarinic receptors have long been identified as a potential therapeutic target for the treatment of cognitive impairment in Alzheimer's disease (AD). Our previous study has shown that M1 receptors promote membrane insertion and synaptic delivery of AMPA receptor GluA1 subunit. In this study, we sought to determin...

journal_title：Neuroscience

authors： Zhao LX,Chen MW,Qian Y,Yang QH,Ge YH,Chen HZ,Qiu Y

更新日期：2019-06-01 00:00:00